Translational Research and Epithelial Carcinogenesis: Molecular Diagnostic Assays Now--Molecular Screening Assays Soon?

Translational challenges and analgesic screening assays.

Progress in the development of novel treatments for chronic pain syndromes relies, in part, on both clinically-relevant animal model simulations and analgesic screening procedures [5]. Simulations purport to mimic the features of a clinical syndrome and screenings are geared towards drug discovery. The validity of any animal model simulation is based on how well that model fits the human clinic...

Lipase assays for conventional and molecular screening: an overview.

Lipases are versatile biocatalysts that can perform innumerable different reactions. Their enantio-, chemo- and stereo-selective nature makes them an important tool in the area of organic synthesis. Unlike other hydrolases that work in aqueous phase, lipases are unique as they act at the oil/water interface. Besides being lipolytic, lipases also possess esterolytic activity and thus have a wide...

Diagnostic value of molecular confirmation assays for Neisseria gonorrhoeae.

Molecular assays for detection of falcon adenovirus.

Falcon adenovirus is a newly recognized member of the family Aviadenoviridae and includes 2 closely related strains that are pathogenic to several species of falcons. Peregrine falcons appear to be one of the primary reservoirs, but recent outbreaks suggest that other carrier species probably exist. To allow screening of captive birds for virus shedding and investigations of disease outbreaks, ...

Improved internal control for molecular diagnosis assays

The two principal determining steps in molecular diagnosis are the amplification and the identification steps. Accuracy of DNA amplification is primarily determined by the annealing sequence of the PCR primer to the analyte DNA. Accuracy for identification is determined either by the annealing region of a labelled probe for the real time PCR analysis, or the annealing of a sequencing primer for...